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KMID : 1123920050190030736
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 3 p.736 ~ p.742
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Inhibiting and Repairing Effects of Bojung-ikki-tang Gamibang on Cyclophosphamide induced Bone Marrow Injuries in Rats
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Kim Dong-Woo
Ko Heung
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Abstract
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This study was carried out to investigate the inhibiting and repairing effects of Bojung-ikki-tang Gamibang(BI-G) on the bone marrow injuries in rats. Bone marrow injury was induced by a single intraperitoneal injection of cyclophosphamide(CP)(150mg/kg). In experiment I, designed for inhibiting effect, extract of BI-G(80mg) was administrated from pre-5 days to post-5 days of CP injection. In experiment II, designed for repairing effect, extract of BI-G(80mg) was administrated after 5 days to 12 days of CP injection. Hematological and histopathological examinations were performed at 5 days after CP injection in experiment I, and at 12 days after CP injection in experiment II. In experiment I, the results were as follows ; RBC() of BI-G treated group was increased significantly compared with control group. Hemoglobin(g/dl) of BI-G treated group was increased significantly compared with control group. WBC() of BI-G treated group was increased significantly compared with control group. Necrotic changes of myeloid cells of BI-G treated group were less severe than those of control group. Histopathologically, distention of sinus and edematous changes of bone marrow of BI-G treated group were alleviated compared with those of control group. In experiment II, the results were as follows ; WBC() of BI-G treated group(4.27 0.94) was increased significantly compared with control group. Hemoglobin(g/dl) of BI-G treated group was increased significantly compared with control group. Platelets() of BI-G treated group was increased significantly compared with control group. These results indicated that Bojung-ikki-tang Gamibang has the inhibiting and repairing effects on the cyclophosphamide-induced bone marrow injuries in rats.
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KEYWORD
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Bojung-ikki-tang Gamibang(BI-G), hematopoiesis, bone marrow, cyclophosphamide, WBC
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